2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-20019R
    L-165041 (Standard) 79558-09-1
    L-165041 (Standard) is the analytical standard of L-165041. This product is intended for research and analytical applications. L-165041 is a cell permeable PPARδ agonist, with Kis of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively, and induces adipocyte differentiation in NIH-PPARδ cells.
    L-165041 (Standard)
  • HY-200306
    DMTr-2'-O-C16-rU-3'-CE-phosphoramidite 2382942-83-6 98.16%
    DMTr-2'-O-C16-rU-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C16-rU-3'-CE-phosphoramidite
  • HY-200316
    DMTr-2'-O-Methyl palmitate-rU-3'-CE-phosphoramidite 2642320-25-8 98%
    DMTr-2'-O-(Methyl palmitate)-rU-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Methyl palmitate-rU-3'-CE-phosphoramidite
  • HY-203025
    Im-NMN 938173-81-0
    Im-NMN is a monomeric raw material that can be used for nucleic acid synthesis.
    Im-NMN
  • HY-20696R
    Tetrahydro-β-carboline (Standard) 16502-01-5 98%
    Tetrahydro-β-carboline (Standard) is the analytical standard of Tetrahydro-β-carboline. This product is intended for research and analytical applications. Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 μM.
    Tetrahydro-β-carboline (Standard)
  • HY-21065R
    Tienilic acid (Standard) 40180-04-9
    Tienilic acid (Standard) is the analytical standard of Tienilic acid. This product is intended for research and analytical applications. Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro.
    Tienilic acid (Standard)
  • HY-21586A
    m7GTP 26554-26-7 98%
    7-Methyl-guanosine-5'-triphosphate (m7GTP) is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate phosphorothioate analog is a potent cap-dependent translation inhibitor.
    m7GTP
  • HY-28229A
    2(E)-Nonenedioic acid 757219-33-3 98%
    2(E)-Nonenedioic acid ((2E)-2-Nonenedioic acid) is an ester product.
    2(E)-Nonenedioic acid
  • HY-30220R
    (S)-2-Hydroxy-3-phenylpropanoic acid (Standard) 20312-36-1 98%
    (S)-2-Hydroxy-3-phenylpropanoic acid (Standard) is the analytical standard of (S)-2-Hydroxy-3-phenylpropanoic acid. This product is intended for research and analytical applications. (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria.
    (S)-2-Hydroxy-3-phenylpropanoic acid (Standard)
  • HY-32337R
    Tacalcitol (Standard) 57333-96-7
    Tacalcitol (Standard) is the analytical standard of Tacalcitol. This product is intended for research and analytical applications. Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases.
    Tacalcitol (Standard)
  • HY-32349R
    Ercalcidiol (Standard) 21343-40-8
    Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
    Ercalcidiol (Standard)
  • HY-34439R
    2,5-Dimethylpyrazine (Standard) 123-32-0 98%
    2,5-Dimethylpyrazine (Standard) is the analytical standard of 2,5-Dimethylpyrazine. This product is intended for research and analytical applications. 2,5-Dimethylpyrazine is an endogenous metabolite.
    2,5-Dimethylpyrazine (Standard)
  • HY-34516R
    D-Ornithine hydrochloride (Standard) 16682-12-5
    D-Ornithine (hydrochloride) (Standard) is the analytical standard of D-Ornithine (hydrochloride). This product is intended for research and analytical applications. D-Ornithine ((R)-Ornithine) hydrochloride is a constituent of bacterial cell wall. D-Ornithine hydrochloride promotes the production of L-arginine (HY-N0455). D-Ornithine hydrochloride enhances the expression of pyrrolysine-containing proteins.
    D-Ornithine hydrochloride (Standard)
  • HY-400930
    2',3'-Di-O-iBu-rG(iBu) 56489-75-9
    2',3'-Di-O-iBu-rG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.
    2',3'-Di-O-iBu-rG(iBu)
  • HY-42680R
    D-Tagatose (Standard) 87-81-0 98%
    D-Tagatose (Standard) is the analytical standard of D-Tagatose (HY-42680). This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.
    D-Tagatose (Standard)
  • HY-45609R
    L-Cysteine S-sulfate sodium hydrate (Standard) 150465-29-5
    L-Cysteine S-sulfate sodium hydrate (Standard) is the analytical standard of L-Cysteine S-sulfate sodium hydrate (HY-45609). This product is intended for research and analytical applications. L-Cysteine S-sulfate sodium hydrate is an S-sulfated derivative of L-cysteine (HY-Y0337). L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry and chromatography analyses.
    L-Cysteine S-sulfate sodium hydrate (Standard)
  • HY-50289R
    Sorbinil (Standard) 68367-52-2 98%
    Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
    Sorbinil (Standard)
  • HY-50670R
    DGAT-1 inhibitor 2 (Standard) 942999-61-3 98%
    DGAT-1 inhibitor 2 (Standard) is the analytical standard of DGAT-1 inhibitor 2 (HY-50670). This product is intended for research and analytical applications. DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC50 values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity.
    DGAT-1 inhibitor 2 (Standard)
  • HY-50691R
    GW-1100 (Standard) 306974-70-9
    GW-1100 (Standard) is the analytical standard of GW-1100. This product is intended for research and analytical applications. GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.
    GW-1100 (Standard)
  • HY-50911R
    Turofexorate isopropyl (Standard) 629664-81-9 98%
    Turofexorate isopropyl (Standard) is the analytical standard of Turofexorate isopropyl. This product is intended for research and analytical applications. Turofexorate isopropyl (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM.
    Turofexorate isopropyl (Standard)
Cat. No. Product Name / Synonyms Application Reactivity